Publication Highlights

2023

• Safety, Tolerability, and Pharmacokinetics of β-Cryptoxanthin Supplementation in Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.
  Tan KML, Chee J, Lim KLM, Ng M, Gong M, Xu J, Tin F, Natarajan P, Lee BL, Ong CN, Tint MT, Kee MZL, Müller-Riemenschneider F, Gluckman PD, Meaney MJ, Kumar M, Karnani N, Eriksson JG, Nandanan B, Wyss A, Cameron-Smith D.
  Nutrients. 2023 May 16;15(10):2325. doi: 10.3390/nu15102325.
• Evidence for inefficient contraction and abnormal mitochondrial activity in sarcopenia using magnetic resonance spectroscopy.
  Stephenson MC, Ho JXM, Migliavacca E, Kalimeri M, Karnani N, Banerji S, Totman JJ, Feige JN, Merchant RA, Tay SKH.
  J Cachexia Sarcopenia Muscle. 2023 May 4. doi: 10.1002/jcsm.13220.
• A five-safes approach to a secure and scalable genomics data repository.
  Shih CC, Chen J, Lee AS, Bertin N, Hebrard M, Khor CC, Li Z, Juan Tan JH, Meah WY, Peh SQ, Mok SQ, Sim KS, Liu J, Wang L, Wong E, Li J, Tin A, Cheng CY, Heng CK, Yuan JM, Koh WP, Saw SM, Friedlander Y, Sim X, Chai JF, Chong YS, Davila S, Goh LL, Lee ES, Wong TY, Karnani N, Leong KP, Yeo KK, Chambers JC, Lim SC, Goh RSM, Tan P, Dorajoo R.
  iScience. 2023 Mar 31;26(4):106546. doi: 10.1016/j.isci.2023.106546. eCollection 2023 Apr 21.
• Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study.
  Chen L, Mir SA, Bendt AK, Chua EWL, Narasimhan K, Tan KM, Loy SL, Tan KH, Shek LP, Chan J, Yap F, Meaney MJ, Chan SY, Chong YS, Gluckman PD, Eriksson JG, Karnani N, Wenk MR.
  BMC Med. 2023 Feb 13;21(1):53. doi: 10.1186/s12916-023-02740-x.
• The Singapore National Precision Medicine Strategy.
  Wong E, Bertin N, Hebrard M, Tirado-Magallanes R, Bellis C, Lim WK, Chua CY, Tong PML, Chua R, Mak K, Lim TM, Cheong WY, Thien KE, Goh KT, Chai JF, Lee J, Sung JJ, Wong TY, Chin CWL, Gluckman PD, Goh LL, Ban KHK, Tan TW; SG10K_Health Consortium; Sim X, Cheng CY, Davila S, Karnani N, Leong KP, Liu J, Prabhakar S, Maurer-Stroh S, Verma CS, Krishnaswamy P, Goh RSM, Chia I, Ho C, Low D, Virabhak S, Yong J, Zheng W, Seow SW, Seck YK, Koh M, Chambers JC, Tai ES, Tan P.
  Nat Genet. 2023 Jan 19. doi: 10.1038/s41588-022-01274-x.
• Timing of introduction of complementary foods, breastfeeding, and child cardiometabolic risk: a prospective multiethnic Asian cohort study.
  Ong YY, Pang WW, Michael N, Aris IM, Sadananthan SA, Tint MT, Liang Choo JT, Ling LH, Karnani N, Velan SS, Fortier MV, Tan KH, Gluckman PD, Yap F, Chong YS, Godfrey KM, Chan SY, Eriksson JG, Chong MF, Wlodek ME, Lee YS.
  Am J Clin Nutr. 2023 Jan;117(1):83-92. doi: 10.1016/j.ajcnut.2022.10.021. Epub 2022 Dec 21.
• Profiling Microbial Communities in Idiopathic Granulomatous Mastitis.
  Ong SS, Xu J, Sim CK, Khng AJ, Ho PJ, Kwan PKW, Ravikrishnan A, Tan KB, Tan QT, Tan EY, Tan SM, Putti TC, Lim SH, Tang ELS, Nagarajan N, Karnani N, Li J, Hartman M.
  Int J Mol Sci. 2023 Jan 5;24(2):1042. doi: 10.3390/ijms24021042.

2022

• Analysis of clinically relevant variants from ancestrally diverse Asian genomes.
  Chan SH, Bylstra Y, Teo JX, Kuan JL, Bertin N, Gonzalez-Porta M, Hebrard M, Tirado-Magallanes R, Tan JHJ, Jeyakani J, Li Z, Chai JF, Chong YS, Davila S, Goh LL, Lee ES, Wong E, Wong TY; SG10K_Health Consortium, Prabhakar S, Liu J, Cheng CY, Eisenhaber B, Karnani N, Leong KP, Sim X, Yeo KK, Chambers JC, Tai ES, Tan P, Jamuar SS, Ngeow J, Lim WK.
  Nat Commun. 2022 Nov 5;13(1):6694. doi: 10.1038/s41467-022-34116-9.

• Prenatal Diet, Plasma Micronutrients/Metabolome And Inflammatory Status Influence The Development Of Atopic Eczema In Early Childhood.
  Ta LDH, Chan JCY, Yap GC, Huang CH, Tham EH, Loo EXL, Suaini NHA, Shek LPC, Karnani N, Goh A, Bever HPSV, Teoh OH, Chan YH, Lay C, Knol J, Yap F, Tan KH, Chong YS, Chong MF, Chan SY, Eriksson JG, Godfrey KM, Chan ECY, Lee BW.
  Allergy. 2022 Nov 2. doi: 10.1111/all.15573.

• Associations of maternal and foetoplacental factors with prehypertension/hypertension in early childhood.
  Michael N, Sadananthan SA, Yuan WL, Ong YY, Loy SL, Huang JY, Tint MT, Padmapriya N, Choo J, Ling LH, Kramer MS, Godfrey KM, Gluckman PD, Tan KH, Eriksson JG, Chong YS, Lee YS, Karnani N, Yap F, Shek LP, Fortier MV, Moritz KM, Chan SY, Velan SS, Wlodek ME.
  J Hypertens. 2022 Nov 1;40(11):2171-2179. doi: 10.1097/HJH.0000000000003241. Epub 2022 Jul 22.

• Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood.
  Michael N, Gupta V, Fogel A, Huang J, Chen L, Sadananthan SA, Ong YY, Aris IM, Pang WW, Yuan WL, Loy SL, Thway Tint M, Tan KH, Chan JK, Chan SY, Shek LP, Yap F, Godfrey K, Chong YS, Gluckman P, Velan SS, Forde CG, Lee YS, Eriksson JG, Karnani N.
  Int J Epidemiol. 2022 Sep 10:dyac177. doi: 10.1093/ije/dyac177.

• Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms.
  Kee MZL, Teh AL, Clappison A, Pokhvisneva I, MacIssac JL, Lin DTS, Ramadori KE, Broekman BFP, Chen H, Daniel ML, Karnani N, Kobor MS, Gluckman PD, Chong YS, Huang JY, Meaney MJ.
  iScience. 2022 Aug 4;25(9):104860. doi: 10.1016/j.isci.2022.104860. eCollection 2022 Sep 16.

• Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study.
  Mir SA, Chen L, Burugupalli S, Burla B, Ji S, Smith AAT, Narasimhan K, Ramasamy A, Tan KM, Huynh K, Giles C, Mei D, Wong G, Yap F, Tan KH, Collier F, Saffery R, Vuillermin P, Bendt AK, Burgner D, Ponsonby AL, Lee YS, Chong YS, Gluckman PD, Eriksson JG, Meikle PJ, Wenk MR, Karnani N.
  BMC Med. 2022 Jul 25;20(1):242. doi: 10.1186/s12916-022-02432-y.

• Allergic sensitization trajectories to age 8 years in the Singapore GUSTO cohort.
  Lau HX, Chen Z, Chan YH, Tham EH, Goh AEN, Van Bever H, Teoh OH, Karnani N, Gluckman PD, Tan KH, Yap FKP, Godfrey KM, Eriksson JG, Chong YS, Lee BW, Shek LP, Loo EXL.
  World Allergy Organ J. 2022 Jul 14;15(7):100667. doi: 10.1016/j.waojou.2022.100667. eCollection 2022 Jul.

• Machine Learning-Derived Prenatal Predictive Risk Model to Guide Intervention and Prevent the Progression of Gestational Diabetes Mellitus to Type 2 Diabetes: Prediction Model Development Study.
  Kumar M, Ang LT, Ho C, Soh SE, Tan KH, Chan JKY, Godfrey KM, Chan SY, Chong YS, Eriksson JG, Feng M, Karnani N.
  JMIR Diabetes. 2022 Jul 5;7(3):e32366. doi: 10.2196/32366.

• Evaluation of Stool Short Chain Fatty Acids Profiles in the First Year of Life With Childhood Atopy-Related Outcomes.
  Cheng HY, Chan JCY, Yap GC, Huang CH, Kioh DYQ, Tham EH, Loo EXL, Shek LPC, Karnani N, Goh A, Van Bever HPS, Teoh OH, Chan YH, Lay C, Knol J, Yap F, Tan KH, Chong YS, Godfrey KM, Chan ECY, Lee BW, Ta LDH.
  Front Allergy. 2022 Apr 6;3:873168. doi: 10.3389/falgy.2022.873168. eCollection 2022.

• Automated Machine Learning (AutoML)-Derived Preconception Predictive Risk Model to Guide Early Intervention for Gestational Diabetes Mellitus.
  Kumar M, Ang LT, Png H, Ng M, Tan K, Loy SL, Tan KH, Chan JKY, Godfrey KM, Chan SY, Chong YS, Eriksson JG, Feng M, Karnani N.
  Int J Environ Res Public Health. 2022 Jun 1;19(11):6792. doi: 10.3390/ijerph19116792.

• Activated Brown Adipose Tissue Releases Exosomes Containing Mitochondrial Methylene Tetrahydrofolate Dehydrogenase (NADP-dependent) 1-Like Protein (MTHFD1L).
  Leow MK, Rengaraj A, Narasimhan K, Verma SK, Jadegoud Y, Thu GLT, Sun L, Goh HJ, Govindharajulu P, Sadananthan SA, Michael N, Meng W, Gallart-Palau X, Sun L, Karnani N, Sze NSK, Velan SS.
  Biosci Rep. 2022 May 3:BSR20212543. doi: 10.1042/BSR20212543.

• Integrative Multi-Omics database (iMOMdb) of Asian Pregnant Women.
  Pan H, Tan PF, Lim IY, Huan J, Teh AL, Chen L, Gong M, Tin F, Mir SA, Narasimhan K, Chan JKY, Tan KH, Kobor MS, Meikle PJ, Wenk MR, Chong YS, Eriksson JG, Gluckman PD, Karnani N.
  Hum Mol Genet. 2022 Apr 21:ddac079. doi: 10.1093/hmg/ddac079.

• Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children.
  Loo EXL, Ooi DSQ, Ong M, Ta LDH, Lau HX, Tay MJY, Yap QV, Chan YH, Tham EH, Goh AEN, Van Bever H, Teoh OH, Eriksson JG, Chong YS, Gluckman P, Yap FKP, Karnani N, Xu J, Tan KML, Tan KH, Lee BW, Kramer M, Shek LP, Meaney MJ, Broekman BFP.
  Front Pediatr. 2022 Mar 30;10:837741. doi: 10.3389/fped.2022.837741.

• The socioeconomic landscape of the exposome during pregnancy.
  Sum KK, Tint MT, Aguilera R, Dickens BSL, Choo S, Ang LT, Phua D, Law EC, Ng S, Tan KM, Benmarhnia T, Karnani N, Eriksson JG, Chong YS, Yap F, Tan KH, Lee YS, Chan SY, Chong MFF, Huang J.
  Environ Int. 2022 Mar 26;163:107205. doi: 10.1016/j.envint.2022.107205.

• Ontogeny of circulating lipid metabolism in pregnancy and early childhood: a longitudinal population study.
  Burugupalli S, Smith AAT, Oshlensky G, Huynh K, Giles C, Wang T, George A, Paul S, Nguyen A, Duong T, Mellett N, Cinel M, Mir SA, Chen L, Wenk MR, Karnani N, Collier F, Saffery R, Vuillermin P, Ponsonby AL, Burgner D, Meikle P.
  Elife. 2022 Mar 2;11:e72779. doi: 10.7554/eLife.72779.

• Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero.
  Ong YY, Pang WW, Huang JY, Aris IM, Sadananthan SA, Tint MT, Yuan WL, Chen LW, Chan YH, Karnani N, Velan SS, Fortier MV, Choo J, Ling LH, Shek L, Tan KH, Gluckman PD, Yap F, Chong YS, Godfrey KM, Chong MF, Chan SY, Eriksson JG, Wlodek ME, Lee YS, Michael N.
  Eur J Nutr. 2022 Feb 6. doi: 10.1007/s00394-022-02800-7.

• Population-centric Risk Prediction Modeling for Gestational Diabetes Mellitus: A Machine Learning Approach.
  Kumar M, Chen L, Tan K, Ting Ang L, Ho C, Wong G, Soh SE, Hian Tan K, Kok Yen Chan J, Godfrey KM, Chan SY, Foong Fong Chong M, Connolly JE, Seng Chong Y, Eriksson JG, Feng M, Karnani N.
  Diabetes Res Clin Pract. 2022 Feb 4:109237. doi: 10.1016/j.diabres.2022.109237.

• Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies.
  Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Dabelea D, Felix JF, Heude B, Jaddoe VWV, Lahti J, Reimann B, Vääräsmäki M, Bonnefond A, Froguel P, Hummel S, Kajantie E, Jarvelin MR, Steegers-Theunissen RPM, Howe CG, Hivert MF, Sebert S.
  Diabetes Care. 2022 Mar 1;45(3):614-623. doi: 10.2337/dc21-1701.

• Variability in newborn telomere length is explained by inheritance and intrauterine environment.
  Chen L, Ling KTM, Gong M, Chong MFF, Tan KH, Chong YS, Meaney MJ, Gluckman PD, Eriksson JG, Karnani N.
  BMC Med. 2022 Jan 25;20(1):20. doi: 10.1186/s12916-021-02217-9.

2021

• Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution.
  Tan K, Tint MT, Michael N, Yap F, Chong YS, Tan KH, Godfrey KM, Larbi A, Lee YS, Chan SY, Fortier MV, Eriksson JG, Karnani N.
  Int J Obes (Lond). 2021 Dec 4. doi: 10.1038/s41366-021-00975-3.

• Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome.
  Lim IY, Lin X, Teh AL, Wu Y, Chen L, He M, Chan SY, MacIsaac JL, Chan JKY, Tan KH, Chong MFF, Kobor MS, Godfrey KM, Meaney MJ, Lee YS, Eriksson JG, Gluckman PD, Chong YS, Karnani N.
  J Clin Endocrinol Metab. 2021 Oct 11:dgab710.

• Role of maternal tryptophan metabolism in allergic diseases in the offspring.
  Lau HX, El-Heis S, Yap QV, Chan YH, Tan CPT, Karnani N, Tan KML, Tham EH, Goh AEN, Teoh OH, Tan KH, Eriksson JG, Chong YS, Chong MF, Van Bever H, Lee BW, Shek LP, Godfrey KM, Loo EXL.
  Clin Exp Allergy. 2021 Oct;51(10):1346-1360.

• Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach.
  Huang JY, Cai S, Huang Z, Tint MT, Yuan WL, Aris IM, Godfrey KM, Karnani N, Lee YS, Chan JKY, Chong YS, Eriksson JG, Chan SY.
  Nat Commun. 2021 Sep 23;12(1):5613.

• Genetic Link Determining the Maternal-Fetal Circulation of Vitamin D
  Sampathkumar A, Tan KM, Chen L, Chong MFF, Yap F, Godfrey KM, Chong YS, Gluckman PD, Ramasamy A, Karnani N.
  J Front Genet. 2021 Sep 21;12:721488.

• Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
  McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O’Donnell KJ.
  Biol Psychiatry. 2021 Aug 19:S0006-3223(21)01527-4.

• Brown adipose tissue, adiposity and metabolic profile in preschool children.
  Tint MT, Michael N, Sadananthan SA, Huang JY, Khoo CM, Godfrey KM, Shek LP, Lek N, Tan KH, Yap F, Velan SS, Gluckman PD, Chong YS, Karnani N, Chan SY, Leow MK, Lee KJ, Lee YS, Hu HH, Zhang C, Fortier MV, Eriksson JG.
  J Clin Endocrinol Metab. 2021 Jun 18:dgab447.

• Cardiometabolic Profile of Different Body Composition Phenotypes in Children.
  Ong YY, Huang JY, Michael N, Sadananthan SA, Yuan WL, Chen LW, Karnani N, Velan SS, Fortier MV, Tan KH, Gluckman PD, Yap F, Chong YS, Godfrey KM, Chong MF, Chan SY, Lee YS, Tint MT, Eriksson JG.
  J Clin Endocrinol Metab. 2021 Apr 23;106(5):e2015-e2024.

• The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring.
  Wong G, Weir JM, Mishra P, Huynh K, Nijagal B, Gupta V, Broekman BFP, Chong MF, Chan SY, Tan KH, Tull D, McConville M, Calder PC, Godfrey KM, Chong YS, Gluckman PD, Meaney MJ, Meikle PJ, Karnani N.
  Transl Psychiatry. 2021 Feb 4;11(1):107.

2020

• Association of Cord Blood Thyroid-Stimulating Hormone Levels with Maternal, Delivery and Infant Factors.
  Tan KML, Chu AHY, Loy SL, Rajadurai VS, Ho CKM, Chong YS, Karnani N, Lee YS, Yap FKP, Chan SY.
  Ann Acad Med Singap. 2020 Dec;49(12):937-947.

• Complex genetic dependencies among growth and neurological phenotypes in healthy children: Towards deciphering developmental mechanisms.
  Uechi L, Jalali M, Wilbur JD, French JL, Jumbe NL, Meaney MJ, Gluckman PD, Karnani N, Sakhanenko NA, Galas DJ; GUSTO study group.
  PLoS One. 2020 Dec 3;15(12):e0242684.

• COVID-19 endocrinopathy with hindsight from SARS.
  Kothandaraman N, Anantharaj R, Xue B, Yew WS, Velan SS, Karnani N, Leow MK.
  Am J Physiol Endocrinol Metab. 2020 Nov 25.

• Cohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO).
  Loo EXL, Soh SE, Loy SL, Ng S, Tint MT, Chan SY, Huang JY, Yap F, Tan KH, Chern BSM, Tan HH, Meaney MJ, Karnani N, Godfrey KM, Lee YS, Chan JKY, Gluckman PD, Chong YS, Shek LP, Eriksson JG; S-PRESTO Study Group, Chia A, Fogel AM, Goh AEN, Chu AHY, Rifkin-Graboi A, Qiu A, Lee BW, Cheon BK, Vaz C, Henry CJ, Forde CG, Chi C, Koh DXP, Phua DY, Loh DNL, Quah EPL, Tham EH, Law ECN, Magkos F, Mueller-Riemenschneider F, Yeo GSH, Yong HEJ, Chen HY, Tan HH, Pan H, Bever HPSV, Tan HM, Aris IBM, Tay J, Chan JKY, Xu J, Yoong JS, Eriksson JG, Choo JTL, Bernard JY, Huang JY, Lai JS, Tan KML, Godfrey KM, Kwek KYC, McCrickerd K, Narasimhan K, Chong KW, Lee KJ, Chen L, Ling LH, Chen LW, Daniel LM, Shek LP, Fortier MV, Chong MF, Chua MC, Leow MK, Kee MZL, Gong M, Tint MT, Michael N, Lek N, Teoh OH, Mishra P, Li QLJ, Velan SS, Ang SB, Cai S, Goh SH, Lim SB, Tsotsi S, Hsu SC, Toh SES, Sadananthan SA, Tan TH, Yew TW, Gupta V, Rajadurai VS, Han WM, Pang WW, Yuan WL, Zhu Y, Cheung YB, Chan YH, Cheng ZR.
  Eur J Epidemiol. 2020 Nov 21.

• A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema.
  Ta LDH, Chan JCY, Yap GC, Purbojati RW, Drautz-Moses DI, Koh YM, Tay CJX, Huang CH, Kioh DYQ, Woon JY, Tham EH, Loo EXL, Shek LPC, Karnani N, Goh A, Van Bever HPS, Teoh OH, Chan YH, Lay C, Knol J, Yap F, Tan KH, Chong YS, Godfrey KM, Kjelleberg S, Schuster SC, Chan ECY, Lee BW.
  Gut Microbes. 2020 Nov 9;12(1):1-22.

• Mismatch between poor fetal growth and rapid postnatal weight gain in the first 2 years of life is associated with higher blood pressure and insulin resistance without increased adiposity in childhood: the GUSTO cohort study.
  Ong YY, Sadananthan SA, Aris IM, Tint MT, Yuan WL, Huang JY, Chan YH, Ng S, Loy SL, Velan SS, Fortier MV, Godfrey KM, Shek L, Tan KH, Gluckman PD, Yap F, Choo JTL, Ling LH, Tan K, Chen L, Karnani N, Chong YS, Eriksson JG, Wlodek ME, Chan SY, Lee YS, Michael N.
  Int J Epidemiol. 2020 Oct 1;49(5):1591-1603.

• Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets.
  Xu J, Lawley B, Wong G, Otal A, Chen L, Ying TJ, Lin X, Pang WW, Yap F, Chong YS, Gluckman PD, Lee YS, Chong MF, Tannock GW, Karnani N.
  Gut Microbes. 2020 Sep 2;11(5):1362-1373.

• Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study.
  Chia AR, de Seymour JV, Wong G, Sulek K, Han TL, McKenzie EJ, Aris IM, Godfrey KM, Yap F, Tan KH, Shek LP, Lee YS, Kramer MS, Karnani N, Chong MF, Baker PN.
  Sci Rep. 2020 Jun 10;10(1):9422.

• High placental Inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: The GUSTO cohort.
  Chu AHY, Tint MT, Chang HF, Wong G, Yuan WL, Tull D, Nijagal B, Narayana VK, Meikle PJ, Chang KTE, Lewis RM, Chi C, Yap FKP, Tan KH, Shek LP, Chong YS, Gluckman PD, Lee YS, Fortier MV, Godfrey KM, Eriksson JG, Karnani N, Chan SY.
  Int J Obes (Lond). 2020 May 20.

• Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation.
  Chen LW, Xu J, Soh SE, Aris IM, Tint MT, Gluckman PD, Tan KH, Shek LP, Chong YS, Yap F, Godfrey KM, Gilbert JA, Karnani N, Lee YS.
  Int J Obes (Lond). 2020 Apr 22. 

2019

• Mitochondrial oxidative capacity and NAD⁺ biosynthesis are reduced in human sarcopenia across ethnicities. Migliavacca E, Tay SKH, Patel HP, Sonntag T, Civiletto G, McFarlane C, Forrester T, Barton SJ, Leow MK, Antoun E, Charpagne A, Seng Chong Y, Descombes P, Feng L, Francis-Emmanuel P, Garratt ES, Giner MP, Green CO, Karaz S, Kothandaraman N, Marquis J, Metairon S, Moco S, Nelson G, Ngo S, Pleasants T, Raymond F, Sayer AA, Ming Sim C, Slater-Jefferies J, Syddall HE, Fang Tan P, Titcombe P, Vaz C, Westbury LD, Wong G, Yonghui W, Cooper C, Sheppard A, Godfrey KM, Lillycrop KA, Karnani N, Feige JN.
  Nat Commun. 2019 Dec 20;10(1):5808.   

• circASXL1-1 regulates BAP1 deubiquitinase activity in leukemia.
  Jadhav S, Kumari N, Ng L, Tan PF, Yeo-Teh NSL, Goh Y, Fam WN, Tng JQ, Tian JS, Koh BTH, Chun CM, Wang W, Chng WJ, Fullwood MJ, Guccione E, Karnani N, Tenen DG, Jha S.
  Haematologica 2019 Nov 28. 

• The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.
  McEwen LM, O’Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS.
  Proc Natl Acad Sci U S A. 2019 Oct 14.

• Large-scale Whole-Genome Sequencing of three diverse Asian populations in Singapore.
  Wu D, Dou J, Chai X, Bellis C, Wilm A, Shih CC, Soon WWJ, Bertin N, Lin CB, Khor CC, DeGiorgio M, Cheng S, Bao L, Karnani N, Hwang WYK, Davila S, Tan P, Shabbir A, Moh A, Tan EK, Foo JN, Goh LL, Leong KP, Foo RSY, Lam CSP, Richards AM, Cheng CY, Aung T, Wong TY, Ng HH; SG10K Consortium, Liu J, Wang C.
  Cell. 2019 Oct 17;179(3):736-749.

• Determinants of intramyocellular lipid accumulation in early childhood.
  Michael N, Gupta V, Sadananthan SA, Sampathkumar A, Chen L, Pan H, Tint MT, Lee KJ, Loy SL, Aris IM, Shek LP, Yap FKP, Godfrey KM, Leow MK, Lee YS, Kramer MS, Henry CJ, Fortier MV, Seng Chong Y, Gluckman PD, Karnani N, Velan SS.
  Int J Obes (Lond). 2019 Aug 28.

• Myo-inositol alters 13C-labeled fatty acid metabolism in human placental explants.
  Watkins OC, Islam MO, Selvam P, Pillai RA, Cazenave-Gassiot A, Bendt AK, Karnani N, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
  J Endocrinol. 2019 Aug 1. pii: JOE-19-0267.R1.

• Metabolism of 13C-labeled fatty acids in term human placental explants by liquid chromatography-mass spectrometry.
  Watkins OC, Islam MO, Selvam P, Pillai RA, Cazenave-Gassiot A, Bendt AK, Karnani N, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
  Endocrinology. 2019 Jun 1;160(6):1394-1408.

• In-utero epigenetic factors are associated with early-onset myopia in young children.
  Seow WJ, Ngo CS, Pan H, Barathi VA, Tompson SW, Whisenhunt KN, Vithana E, Chong YS, Juo SH, Hysi P, Young TL, Karnani N, Saw SM.
  PLoS One. 2019 May 17;14(5):e0214791.

• Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome.
  Ong ML, Tuan TA, Poh J, Teh AL, Chen L, Pan H, MacIsaac JL, Kobor MS, Chong YS, Kwek K, Saw SM, Godfrey KM, Gluckman PD, Fortier MV, Karnani N, Meaney MJ, Qiu A, Holbrook JD.
  Genes Brain Behav. 2019 Apr 24:e12576.

• FUT2 genetic variants and reported respiratory and gastrointestinal illnesses during infancy.
  Barton SJ, Murray R, Lillycrop KA, Inskip HM, Harvey NC, Cooper C, Karnani N, Zolezzi IS, Sprenger N, Godfrey KM, Binia A.
  J Infect Dis. 2019 Feb 15;219(5):836-843.

• Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.
  Wu Y, Lin X, Lim IY, Chen L, Teh AL, MacIsaac JL, Tan KH, Kobor MS, Chong YS, Gluckman PD, Karnani N.
  Clin Epigenetics. 2019 Feb 11;11(1):26.

• Association between early life weight gain and abdominal fat partitioning at 4.5 years is sex, ethnicity, and age dependent.
  Sadananthan SA, Tint MT, Michael N, Aris IM, Loy SL, Lee KJ, Shek LP, Yap FKP, Tan KH, Godfrey KM, Leow MK, Lee YS, Kramer MS, Gluckman PD, Chong YS, Karnani N, Henry CJ, Fortier MV, Velan SS.
  Obesity (Silver Spring). 2019 Feb 1.

• HOXA9 is a novel myopia risk gene.
  Liang CL, Hsu PY, Ngo CS, Seow WJ, Karnani N, Pan H, Saw SM, Juo SH.
  BMC Ophthalmol. 2019 Jan 23;19(1):28.

2018

• Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types.
  Lin X, Tan JYL, Teh AL, Lim IY, Liew SJ, MacIsaac JL, Chong YS, Gluckman PD, Kobor MS, Cheong CY,  Karnani N.
  Epigenetics. 2018;13(9):941-958.

• Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP).
  Rashid MBMA, Toh TB, Hooi L, Silva A, Zhang Y, Tan PF, Teh AL, Karnani N, Jha S, Ho CM, Chng WJ, Ho D, Chow EK.
  Sci Transl Med. 2018 Aug 8;10(453).

• The early care environment and DNA methylome variation in childhood.
  Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O’Donnell KJ; Mavan Study Team.
  Dev Psychopathol. 2018 Aug;30(3):891-903.

• TIP60 represses activation of endogenous retroviral elements.
  Rajagopalan D, Tirado-Magallanes R, Bhatia SS, Teo WS, Sian S, Hora S, Lee KK, Zhang Y, Jadhav SP, Wu Y, Gan YH, Karnani N, Benoukraf T, Jha S.
  Nucleic Acids Res. 2018 Oct 12;46(18):9456-9470.

• Long-chain polyunsaturated fatty acids, gestation duration, and birth size: a Mendelian randomization study using fatty acid desaturase variants.
  Bernard JY, Pan H, Aris IM, Moreno-Betancur M, Soh SE, Yap F, Tan KH, Shek LP, Chong YS, Gluckman PD, Calder PC, Godfrey KM, Chong MF, Kramer MS, Karnani N, Lee YS.
  Am J Clin Nutr. 2018 Jul 1;108(1):92-100.

• Improving mass-univariate analysis of neuroimaging data by modelling important unknown covariates: Application to Epigenome-Wide Association Studies.
  Guillaume B, Wang C, Poh J, Shen MJ, Ong ML, Tan PF, Karnani N, Meaney M, Qiu A.
  Neuroimage. 2018 Jun;173:57-71.

• DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.
  O’Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ.
  Transl Psychiatry. 2018 Jan 10;8(1):15.

2017

• Choice of surrogate tissue influences neonatal EWAS findings.
  Lin X, Teh AL, Chen L, Lim IY, Tan PF, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Lee YS, Holbrook JD, Godfrey KM, Meaney MJ, Kobor MS, Chong YS, Gluckman PD, Karnani N.
  BMC Med. 2017 Dec 5;15(1):211.

• Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study.
  Phua DY, Kee MKZL, Koh DXP, Rifkin-Graboi A, Daniels M, Chen H, Chong YS, Broekman BFP, Magiati I, Karnani N, Pluess M, Meaney MJ; Growing Up In Singapore Towards Healthy Outcomes Study Group.
  Dev Psychopathol. 2017 Dec;29(5):1573-1587.

• Implications of genotype and environment on variation in DNA methylation.
  Lim IY, Lin X, Karnani N.
  Handbook of Nutrition, Diet, and Epigenetics pp 1-20
  

• Effects of antenatal maternal depressive symptoms and socio-economic status on neonatal brain development are modulated by genetic risk.
  Qiu A, Shen M, Buss C, Chong YS, Kwek K, Saw SM, Gluckman PD, Wadhwa PD, Entringer S, Styner M, Karnani N, Heim CM, O’Donnell KJ, Holbrook JD, Fortier MV, Meaney MJ; the GUSTO study group.
  Cereb Cortex. 2017 May 1;27(5):3080-3092.

• ANRIL promoter DNA methylation: A perinatal marker for later adiposity.
  Lillycrop K, Murray R, Cheong C, Teh AL, Clarke-Harris R, Barton S, Costello P, Garratt E, Cook E, Titcombe P, Shunmuganathan B, Liew SJ, Chua YC, Lin X, Wu Y, Burdge GC, Cooper C, Inskip HM, Karnani N, Hopkins JC, Childs CE, Chavez CP, Calder PC, Yap F, Lee YS, Chong YS, Melton PE, Beilin L, Huang RC, Gluckman PD, Harvey N, Hanson MA, Holbrook JD; EpiGen Consortium, Godfrey KM.
  EBioMedicine. 2017 May;19:60-72.

• Gestational diabetes alters functions in offspring’s umbilical cord cells with implications for cardiovascular health.
  Amrithraj AI, Kodali A, Nguyen L, Teo AKK, Chang CW, Karnani N, Ng KL, Gluckman PD, Chong YS, Stünkel W.
  Endocrinology. 2017 Jul 1;158(7):2102-2112.

• Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.
  Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group.
  BMC Med. 2017 Mar 7;15(1):50.

• Obesity – The complex story of its birth.
  Karnani N. Biomedical Central, Blog On Medicine , 2017 Mar 7.

2016

• TIP60 inhibits metastasis by ablating DNMT1−SNAIL2-driven epithelial−mesenchymal transition program.
  Zhang Y, Subbaiah VK, Rajagopalan D, Tham CY, Abdullah LN, Toh TB, Gong M, Tan TZ, Jadhav SP, Pandey AK, Karnani N, Chow EK, Thiery JP, Jha S.
  J Mol Cell Biol. 2016 Sep 20.

• An alternative strategy for pan-acetyl-lysine antibody generation.
  Kim SY, Sim CK, Zhang Q, Tang H, Brunmeir R, Pan H, Karnani N, Han W, Zhang K, Xu F.
  PLoS One. 2016 Sep 8;11(9):e0162528.

• Gene, Environment and Methylation (GEM): A tool suite to efficiently navigate large scale epigenome wide association studies and integrate genotype and interaction between genotype and environment.
  Pan H, Holbrook JD, Karnani N, Kwoh CK.
  BMC Bioinformatics. 2016 Aug 2;17:299.

• Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples.
  Teh AL, Pan H, Lin X, Lim YI, Patro CPK, Cheong CY, Gong M, Meaney MJ, Kobor MS, Chong Y-S, Gluckman PD, Holbrook JD and Karnani N.
  Epigenetics. 2016;11(1):36-48.

• TIP60 inhibits metastasis by ablating DNMT1−SNAIL2-driven epithelial−mesenchymal transition program.
  Zhang Y, Subbaiah VK, Rajagopalan D, Tham CY, Abdullah LN, Toh TB, Gong M, Tan TZ, Jadhav SP, Pandey AK, Karnani N, Chow EK, Thiery JP, Jha S.
  J Mol Cell Biol. 2016 Sep 20.

2015

• Rate of establishing the gut microbiota in infancy has consequences for future health.
  Dogra S, Sakwinska O, Soh SE, Ngom-Bru C, Brück WM, Berger B, Brüssow H, Karnani N, Lee YS, Yap F, Chong YS, Godfrey KM, Holbrook JD.
  Gut Microbes. 2015;6(5):321-5.
  

• Fetal DNA methylation of cortisol-related genes and infant neurobehavior at 6 months: The role of antenatal maternal anxiety.
  Tsotsi S, Abdulla N, Li C, Chong YS, Richmond J, Saw SM, Kwek K, Gluckman PD, Meaney MJ, Holbrook JD, Karnani N, Rifkin-Graboi A.
  Psychoneuroendocrinology 61:35 · November 2015

• HIF3A association with adiposity: the story begins before birth.
  Pan H, Lin X, Wu Y, Chen L, Teh AL, Soh SE, Lee YS, Tint MT, MacIsaac JL, Morin AM, Tan KH, Yap F, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Gluckman PD, Karnani N, Holbrook JD; GUSTO Study Group.
  Epigenomics. 2015;7(6):937-50.
  

2014

• The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes.
  Teh AL, Pan H, Chen L, Ong ML, Dogra S, Wong J, MacIsaac JL, Mah SM, McEwen LM, Saw SM, Godfrey KM, Chong YS, Kwek K, Kwoh CK, Soh SE, Chong MF, Barton S, Karnani N, Cheong CY, Buschdorf JP, Stünkel W, Kobor MS, Meaney MJ, Gluckman PD, Holbrook JD.
  Genome Res. 2014 Jul;24(7):1064-74.